An ultra-concentrated 10 g (40 kcal) WP formulation as a WPM, provided as an RTD solution and consumed 15 min ahead of a lunch meal in people with T2D and overweight or obesity, reduced PPG, increased PP insulin, GLP-1, and BCAA response, and induced an early delay in GE. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.