In individuals with T2D and overweight or obesity, an ultra-concentrated RTD pre-meal formulation of a low dose of WP (10 g; 40 kcal) provided as WPM in a 125 mL solution, shortly (15 min) ahead of a lunch meal, reduced PPG, and increased PP insulin and GLP-1 response. The gene discussed is INS; the disease is type 2 diabetes mellitus.