The results demonstrate that lifelong aerobic exercise activates the AMPK/PGC-1α signaling pathways, which helps counteract the age-related decline in mitochondrial fusion and fission biomarkers, enhances the Beclin1 and LC3-II/LC3-I ratio and decreases p62, and effectively promotes mitochondrial biogenesis, thereby improving mitochondrial quality control and delaying the onset of sarcopenia [18]. The gene discussed is PPARGC1A; the disease is sarcopenia.