The mitochondria-related proteins Drp1, Mfn2, PGC-1α, and COX significantly increased in mice through Sestrin2 in an AMP-activated protein kinase α2 (AMPKα2)-dependent manner following an 8-month treadmill training (60 min/day, 12 m/min) program, suggesting that aerobic exercise enhanced the mitochondrial fusion and fission in gastrocnemius with age-related sarcopenia [62]. The gene discussed is PPARGC1A; the disease is sarcopenia.