A 4-month endurance training (45 min/time, 3 times/week) program in mice enhanced AdipoR1 gene expression, circulating adiponectin levels, AMPK/PGC-1α-related mitochondrial biogenesis, and Akt/mTOR-mediated protein synthesis and proliferation, showcasing positive effects on sarcopenia development and muscle health [74] (Table 1). Here, PPARGC1A is linked to sarcopenia.