Nevertheless, mitochondrial abnormalities are common features of sarcopenia with aging, including disruptions in the proteins responsible for mitochondrial fusion and fission, such as mitofusin1/2 (Mfn1/2) that mediates OMM fusion, optic atrophy 1 (Opa1) that mediates IMM fusion, dynamin-related protein 1 (Drp1), and mitochondrial fission protein 1 (Fis1) [57]. Here, FIS1 is linked to sarcopenia.