FTO and nervous system disorder: Increasing evidence has revealed that hydrogen sulfide is an essential mediator in the brain playing a protective role against neurological disorders.42, Also, our previous work has shown that exposure to arsenic via drinking water leads to neurobehavioral impairments.43 Therefore, we tested whether overexpression of FTO affected arsenic-induced neurobehavioral impairments in mice by using rotarod test, open field test, elevated zero maze, forced swim test and three-chamber sociability and social novelty test, respectively.