After screening the major bacteria involved in FTO-mediated improvements in the intestinal disorders induced by arsenic, the results showed that, when compared with vehicle controls, the abundance of Desulfovibrio fairfieldensis was decreased after treatment of arsenic, but overexpression of FTO significantly enhanced its abundance in FTOKI mice administrated of arsenic in comparison to those in the arsenic alone treated wild type mice (Figure 3(c) and Supplementary Figure S4F). Here, FTO is linked to intestinal disorder.