Patients with confirmed antithrombin, protein C, or protein S deficiency are often candidates for indefinite anticoagulant treatment after a first episode of PE occurring in the absence of a major reversible risk factor and the testing for thrombophilia may be considered, especially when occurring against the family history of PE [7,17,18]. The gene discussed is PROS1; the disease is hyperinsulinemic hypoglycemia, familial, 4.