The analysis categories established from the comprehensive and critical reading of each article were as follows: (A) role of angiotensinogen in cardiovascular diseases, (B) mechanism of action of RNA-based therapies for hypertension treatment, (C) preclinical studies of RNA-based therapies for hypertension, and (D) human studies of RNA-based therapies for hypertension. The gene discussed is AGT; the disease is cardiovascular disorder.