Compared with the control group (OE-NC), the number of α-SMA+ and CD31+ cells in lung metastases of OSTM1 overexpression-group (OE-OSTM1) mice was significantly increased, indicating that the overexpression of OSTM1 could promote angiogenesis in gastric-cancer lung metastases (Figure 3D). This evidence concerns the gene OSTM1 and gastric cancer.