Our research team has recently highlighted the mechanisms of PI resistance in solid tumors, particularly in prostate cancer cell lines, in which autophagic markers, such as LC3 (microtubule-associated proteins 1A/1B light chain 3A, MAP1LC3A, or ATG8E), were found to be significantly upregulated in Bortezomib-resistant cells [43,57]. This evidence concerns the gene MAP1LC3A and prostate carcinoma.