These phytochemicals, derived from plants (e.g., catechins, piperlongumine, lycopene, isoflavone, cucurbitacin, and BPEITC), show significant promise in targeting breast cancer through mechanisms like cell cycle arrest, apoptosis, and inhibition of signaling pathways (e.g., JAK-STAT3, HER2-integrin, MAPK). This evidence concerns the gene STAT3 and breast carcinoma.