The “phosphoinositide 3 kinase (PI3K)\mammalian target of rapamycin (mTOR)\hypoxia-inducible factor-1α (HIF)-1α\vascular endothelial growth factor (VEGF)” signaling pathway, critically involved in cellular responses to hypoxia and oxidative stress conditions prevalent in DN [17], has been experimentally proven as one of the miR-29 target pathways [18]. This evidence concerns the gene MTOR and liver dysplastic nodule.