In 34 patients with HCC and seven different cell line samples analyzed by qRT-PCR and Western blot, Cul7 showed high expression, especially in metastatic tumor tissues; there was a negative correlation between Cul7 expression and long survival, and it was determined that migration, invasion, and metastatic properties were significantly reduced by silencing of Cul7 in liver cancer cells. Here, CUL7 is linked to hepatocellular carcinoma.