Oncogene c-Myc, hypoxia-inducible factor 1-alpha (HIF-1α), p53, erythroid transcription factor (GATA2), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), and Methionine Adenosyltransferase 2A (MAT2A) are also involved in amino acid metabolism, growth, proliferation, and homeostatic balance maintenance in cancer cells. This evidence concerns the gene HIF1A and cancer.