Our findings emphasize the potential utility of the 13-gene WNT-LEF1 signature (RNF43, LEF1, NKD1, AXIN2, DKK4, DKK1, LGR6, FGFR2, NXN, TCF7L1, STK3, YAP1, and NFATC4) in distinguishing WNT-activated medulloblastoma subtypes. The gene discussed is RNF43; the disease is medulloblastoma.