The comparison of MN vs. TCPS in GM and MSCs on TCPS in OM shows that the canonical Wnt pathway is shared through the expression of Frizzled, LRP 5/6, and REPO, but then diverges with cells on MN expressing ICAT, P53, and sphingosine-1-phosphate (SIP), a bioactive lipid mediator, and cells on TCPS in OM favoring the expression of c-JUN, an integral component of the AP-1 transcription factor complex (Table 1). This evidence concerns the gene JUN and ocular melanoma.