MYC and amyloidosis: Since stressful factors, e.g., beta-amyloid oligomers, also induce cell cycle re-entry [137], and the early induction of c-Myc in amyloid-affected cells results in their death, c-Myc, as one of the IEGs, might not directly contribute to the activation of neurons in physiological conditions, but could regulate the elimination of damaged postmitotic neurons.