Consistent with this, an anti-HARE blocking antibody prevented lymph node metastasis following an orthotopic injection of mice with HA-encapsulated metastatic prostate tumor cells, and pretreatment of the animals prior to cell implantation was necessary to prevent metastatic invasion, suggesting HA-coated EVs responsible for HARE-dependent LN invasion were prevented from conditioning the LN niche [76]. Here, STAB2 is linked to prostate neoplasm.