Although GLI1 immunohistochemical staining can help evaluate for GLI1-rearranged enteric tumors, GLI1 expression is not entirely specific, as it is also noted in a subset of other tumor types with secondary GLI1 copy number gains, such as dedifferentiated liposarcomas, leiomyosarcomas, and pleomorphic liposarcomas. The gene discussed is GLI1; the disease is liposarcoma.