The NCOR2::GLI1, HNRNPA1::GLI1, and TUBA1B::GLI1 fusions, although less common, primarily affect gene expression and splicing mechanisms, potentially producing oncogenic protein variants and enhancing GLI1’s transcriptional activity, thereby promoting cancer cell proliferation, invasion, and modulation of inflammatory responses [31,32,33]. The gene discussed is GLI1; the disease is cancer.