On the other hand, GLI1-rearranged enteric tumors may occasionally exhibit high-grade features including a high nuclear-to-cytoplasmic ratio, brisk mitotic activity, and tumor necrosis, with small as well as rhabdoid cell morphologies that may overlap with small, round, and blue cell neoplasms including Ewing sarcoma, CIC-rearranged sarcoma, desmoplastic small round blue cell tumor (DSRBCT), and rhabdomyosarcoma. This evidence concerns the gene GLI1 and sarcoma.