Notably, OGG1, by counteracting 8-oxodG, facilitates NF-κB binding to DNA targets before the removal of 8-oxodG, thereby promoting cancer progression through several mechanisms, such as alterations in the vascular network, the expression and secretion of molecules that modulate innate immunity, and phenotypic transitions between cancer and stromal cells [9]. The gene discussed is OGG1; the disease is cancer.