Several studies have hinted to the importance of IL-1 signaling in pNET microenvironment [75], while sequencing showed the relevance of CD16, IL-1β and NF-κB signaling pathway [76], while PLAUR alterations were identified in Glioblastoma [77] and CEACAM8 in cervical small cell neuroendocrine carcinomas [78]. This evidence concerns the gene CEACAM8 and glioblastoma.