SREBF1 and neoplasm: Previous studies have shown that the activation of PI3K-phospho-AKT (S473)-mechanistic target of rapamycin (mTOR)C1 signaling induces sterol regulatory element-binding protein 1 (SREBP1)-stearoyl-CoA desaturase-1 (SCD1)-mediated monounsaturated fatty acid (MUFA)-containing phospholipid (MUFA-PL) production in the plasma membrane, thus leading to the suppression of ferroptosis in tumor cells [56].