ACSL4 and neoplasm: Yet, it is worth noting that the IKE induction of ferroptosis of MDSCs via absorbing oxidized PL-PUFAs by arachidonate 12/15-lipoxygenase (Alox12/15), ACSL4, or fatty acid transport protein 2 (FATP2) triggers lipid peroxidation and the release of a large number of PGE2, contributing to immunosuppressive activity against antitumor T cells in immunocompetent murine tumor models [6,38,45,46,48,49].