TIPE2 and neoplasm: Instead, IKE-treated TIPE2−/− tumor MDSCs expressed remarkably higher levels of Gpx4, Fsp1, Dhodh, and Slc7a11 genes than IKE-treated WT tumor MDSCs, but no statistical differences in the expression of Gch1 and Slc40a1 genes were noted between IKE-treated TIPE2−/− tumor MDSCs and IKE-treated WT tumor MDSCs (Figure 2d).