However, TIPE2-deficient MDSCs resist IKE-induced ferroptosis through up-regulating the SLC7A11-GPX4 ferroptosis defense systems, and relieve ferroptosis-induced immunosuppressive function by down-regulating ARG1 while promoting T cell proliferation and infiltration into tumor tissues to enhance ferroptosis therapy. The gene discussed is SLC7A11; the disease is neoplasm.