WT and TIPE2−/− mice bearing s.c. LLC or B16F10 tumors were administrated with IKE (one injection every day), or anti-PD-L1 antibody (one injection every three days), or a combination of IKE and anti-PD-L1 antibody for two weeks starting from day 8 post-tumor inoculation (Figure 5a,e). This evidence concerns the gene CD274 and neoplasm.