CHAC1 and neoplasm: Similarly, IKE-treated TIPE2−/− tumor MDSCs also significantly decreased the expression of Vdac2, Sat1, Acsl4, Ho-1, Chac1, and Cars genes, but showed no difference in the expression of Nox1 and Phkg2 genes compared to IKE-treated WT tumor MDSCs (Figure 2c).