Additionally, in this study, TIPE2 deficiency reduced PUFA uptake as well as the accumulation of lipid peroxidation-related PE and PC species, including PE (plasm-18:0/20:4), PE (plasm-18:0/22:4), PE (18:0/22:6), PC (18:0/20:4), PC (18:0/22:4) or PC (18:0/22:6), the ACSL4 protein level, and subsequent lipid ROS production in tumor MDSCs. The gene discussed is ACSL4; the disease is neoplasm.