TIPE2 and neoplasm: While the dual administration of IKE and anti-PD-L1 antibody inhibited LLC or B16F10 tumor growth compared to a single administration of IKE in WT mice, the combination of these two showed even more effectiveness in delaying LLC or B16F10 tumor progression in TIPE2−/− mice when compared with the dual treatment in WT mice (Figure 5b,f).