Similarly, in MC38 (colorectal carcinoma) tumor-bearing mice (Figure S4a), the smallest tumor volume, weight, and size were noted in IKE-treated TIPE2−/− mice compared with the other group (Figure S4b,d,g), and no significant difference in the body weight of all the mice was observed (Figure S4c). The gene discussed is TIPE2; the disease is colorectal carcinoma.