In CAD patients, OPN was positively correlated with 2,3-dinor-8-isoPGF2a (p = 0.02), ornithine (p = 0.01), ADMA (p = 0.001), SDMA (p = 0.03), and citrulline (p = 0.008), potentially explaining the pathophysiology. This evidence concerns the gene SPP1 and coronary artery disorder.