OPN levels were higher in those with triple vessel disease (82.3 ng/mL versus 65.3 ng/mL, p = 0.23), those with insulin-dependent diabetes (170 ng/mL versus 77.3 ng/mL, p = 0.05), or patients with previous acute myocardial infarction (131.5 ng/mL versus 73.3 ng/mL, p = 0.007). This evidence concerns the gene SPP1 and type 1 diabetes mellitus.