MIF exerts its function of promoting leukocyte recruitment to inflammatory sites by noncognate interaction with the chemokine receptors CXCR2 and CXCR4 [48], and regulates the MIF-stimulated survival of macrophages, B cells, and tumor cells through its receptor cluster of differentiation 74 (CD74) [49]. This evidence concerns the gene CXCR4 and neoplasm.