Similarly, the magnitudes of overexpression of genes involved in the TNF-α pathway (see Supplementary Table S4), TGF-β signaling pathway (see Figure 5A,B), NF-κB signaling (see Supplementary Table S4), and IL-17 signaling pathways in BCC were also significantly more in the presence of APC DELs (FC ~3) compared to cases where APC DELs were absent (FC ~1.5) (see Supplementary Table S4). This evidence concerns the gene IL17A and skin basal cell carcinoma.