Furthermore, the AβO-mediated accumulation of striatal-enriched protein tyrosine phosphatase 61 (STEP61) induces the dephosphorylation of the p-Y14782 of NR2B (a subunit of NMDAR), resulting in an increased internalization of NR1/NR2B (NMDAR subunits) that contributes to the cognitive deficits in AD [70,71]. The gene discussed is GRIN2B; the disease is Cognitive impairment.