In addition, the intravitreal administration of rhADAMTS13 restored retinal vascular and BRB integrity and normalized the retinal expression of ICAM-1, VCAM-1, the proinflammatory alarmin HMGB1, and phospho-ERK1/2 in STZ-induced diabetic rats, further corroborating the working hypothesis of rhADAMTS13 as a new therapeutic option for the management of diabetic retinopathy. The gene discussed is HMGB1; the disease is diabetic retinopathy.