A recent study by Sun et al. reported that PDRG1 promotes the proliferation and migration of glioblastoma multiforme both in vivo and in vitro, and that these effects are mediated by the mitogen-activated protein kinase (MEK)–extracellular regulated protein kinase (ERK)/CD44 pathway [53]. The gene discussed is PDRG1; the disease is glioblastoma.