AKT1 and Anxiety: Alongside GlcNAc dysfunction, the downregulation of the insulin signaling pathway components—such as the insulin receptor, IGF-1 receptor, insulin receptor substrate-1, phosphatidylinositide 3-kinases, 3-phosphoinositide-dependent protein kinase-1, protein kinase B, and glycogen synthase kinase-3—has been associated with anxiety-like behavior following cerebral ischemia [124].