Additionally, the upregulation of the angiotensin-converting enzyme/angiotensin II/angiotensin II type 1 receptor (ACE/Ang II/AT1R) axis in the hippocampus, as opposed to the neuroprotective angiotensin-converting enzyme 2/angiotensin-(1–7) (ACE2/Ang-(1–7)) axis results in decreased cerebral blood flow and increased oxidative stress and neuroinflammation, which contributes to the manifestation of anxiety [128]. This evidence concerns the gene ACE2 and Anxiety.