The total leukocyte surface FVIII percentage showed a declining trend across thrombosis, normal, and hypo-coagulation states, and the FVIII on HA patients’ leukocytes was significantly lower in comparison with thrombosis patients’ leukocytes (0.067% versus 0.278%, p = 0.0401, Figure 1a). This evidence concerns the gene F8 and Venous thrombosis.