Recent work demonstrated a tumor suppressor role for RN128 in the colitis-mediated CRC by targeting IL6 receptors and reducing colonic inflammation [146], and RNF61 is shown to ubiquitinate and enhance SNIP1 ubiquitination-mediated degradation to promote cancer metastasis by activating the TGF-β signaling [147]. This evidence concerns the gene TGFB1 and cancer.