In breast cancer, TRAF6/USP17 facilitates asparaginyl endopeptidase (AEP) ubiquitination to promote metastasis [197], whereas Uev1A-Ubc13 promotes CXCL1 expression and NF-κB activation in CRC, enhancing metastatic potential. The gene discussed is NFKB1; the disease is breast carcinoma.