TRIM25 and neoplasm: While most of the tumor modulatory functions of TRIM25 arise from their ubiquitin- or ubiquitin-like posttranslational modifications of protein targets, including sumoylation, neddylation, and interferon-stimulated gene (ISG)ylation, plenty of data indicate that some of the pleiotropic effects by TRIM25 and various other TRIM members can additionally be attributed to a direct regulation of nucleic acids (for a review, see [85]).