Using in vitro transcribed biotinylated mRNA encompassing the complete 5’UTR of caspase-2, we identified TRIM25 as a novel caspase-2 mRNA binding protein in human colorectal carcinoma cells and knockdown analysis confirmed that TRIM25 mainly interfered with the translation of caspase-2 mRNA without affecting caspase-2 mRNA contents (Figure 3). This evidence concerns the gene TRIM25 and colorectal carcinoma.