Furthermore, the authors identified a functional miR365 binding site in the 3’UTR of human TRIM25 mRNA, and the relevance of this TRIM25-antagonizing miR was confirmed by the gain of function experiments demonstrating a strong reduction in TRIM25 expression concomitant with an increased expression of proapoptotic proteins in NSCLC cells. Here, TRIM25 is linked to non-small cell lung carcinoma.