Intriguingly, in addition to promoting tumorigenic functions by NONO indirectly via a suppression of caspase-2 translation, TRIM25 can directly enhance the splicing efficiency of NONO through K64-linked ubiquitination, which is, for example, functionally relevant for the splicing of arginine-methyltransferase-1 (PRMT1) and subsequent activation of the oncogenic c-MYC pathway in glioblastoma [98]. The gene discussed is TRIM25; the disease is glioblastoma.