With respect to this, increased expression levels of various lysosomal proteases, such as CtsB, CtsD, CtsX, and CtsZ, have been detected in patients with ALS and/or mouse models, thus revealing a potential role for these proteases in the onset and/or progression of this pathology [142,143,144,145,146,147], although the contribution of these increased levels to the onset and progression of ALS at the molecular level still remains to be determined. The gene discussed is CTSD; the disease is amyotrophic lateral sclerosis.