In humans, CUL4A has been reported to be amplified in several cancers, including breast cancer [59,60,61], hepatocellular carcinoma [62], squamous cell carcinoma of the esophagus [63], adrenocortical carcinoma [64], non-small cell lung cancer [65], osteosarcoma [66], pleural mesothelioma [67], childhood medulloblastoma [68], epithelial ovarian tumors [69], and prostate cancer [70]. The gene discussed is CUL4A; the disease is breast cancer.