Adrenal insufficiency was confirmed during her third hospitalization with an ACTH stimulation test (basal cortisol: 147.3 nmol/L or 53.4 ng/mL; peak cortisol: 322.4 nmol/L or 116.8 ng/mL; delta: 63.4 ng/mL), so glucocorticoid replacement therapy was continued. This evidence concerns the gene POMC and Adrenal insufficiency.