CD4 and myelodysplastic syndrome: In a later comparative study of TCR repertoires between patients with MDS and controls, Fozza et al. confirmed, using flow cytometry, the expansion of specific TRBV subfamilies in patients compared to the controls, but interestingly, using CDR3 spectratyping, they showed that CD8+ T cell-expanded populations are usually oligoclonal, while CD4+ T cell subsets are mostly polyclonal [26].