A possible explanation for this association found so frequently in those who died from SCD can be represented by the fact that systemic inflammation produces the activation of myofibroblasts with the release of growth factors and cytokines, including increased amounts of transforming growth factor-β1 (TGF-β1) and WNT1-inducible signaling protein-1 (WISP1) which plays an extremely important role in the fibrosis process [47,48]. The gene discussed is CCN4; the disease is Schnyder corneal dystrophy.