IL6 and amyotrophic lateral sclerosis: To begin to determine the pathological significance of IL6 trans-signaling in ALS progression, we initially determined the expression of IL6 in the SOD1G93A mouse tibialis anterior muscle (TA), lumbar spinal cord and lung coincident with the NMJ denervation, glial activation and MN degeneration previously characterized [19,23,24,33,35].