Protein expression levels of ZHX2 on cultured Scl+ hemangioblast-like cells and hemangioblastoma tissues were analyzed by Western blotting, with the following results: expression of ZHX2 was shown in Scl+ hemangioblast-like cells, while cells treated with VHL-expressing adenovirus vector lost expression of ZHX2. The gene discussed is ZHX2; the disease is hemangioblastoma.