In contrast, the activity of pathways from macrophages, such as VEGFB to VEGFR1 and TNFSF13B to TNFRSF13B, was reduced in tumors, possibly reflecting adaptive changes in macrophage function under tumor conditions, which could impact immune responses and tumor cell regulation (Figure 2D, right). The gene discussed is TNFRSF13B; the disease is neoplasm.