As illustrated in Figure 7A, treatment with C5aRA led to a decrease in the expression of the M2 macrophage marker CD206 and an increase in the M1 macrophage marker iNOS. Additionally, flow cytometry analysis indicated that C5aRA treatment reduced the ratio of M2/M1 macrophages within the tumor microenvironment (Figures 7B, C). Here, MRC1 is linked to neoplasm.