The degree of severity of COVID-19, or vulnerability to SARS-CoV-2, depends on many factors, including genetic polymorphisms, which are studied in the following: transmembrane protease serine 2 (TMPRSS2), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and angiotensin-converting enzyme II (De Araújo et al., 2022; Akbari et al., 2022; Zhang et al., 2022). This evidence concerns the gene TMPRSS2 and COVID-19.