Previous studies suggest using BNP as a diagnostic test in patients with breathlessness and other symptoms suggestive of HF (Castiglione et al., 2022; McDonagh et al., 2021; Mueller et al., 2019; Daniels, Mills & Mueller, 2022; Núñez-Marín et al., 2023; Januzzi et al., 2018; Roberts et al., 2015; McCullough et al., 2002). The gene discussed is NPPB; the disease is hydrops fetalis.