NPPB and hydrops fetalis: In another study conducted by Castiglione et al. (2022), the AUC of BNP for the diagnosis of HF at the cut-off point of 100 pg/ml was 0.91, with 90% sensitivity, 76% specificity, and 83% accuracy in 1,586 patients admitted to the emergency department because of new-onset dyspnea.