Similar observations were noted in three families with ID, psychomotor retardation, microcephaly, and dysmorphic features, each carrying a microdeletion or microduplication of just the CNTN6 gene, and in two boys with ID and ASD, one with a microdeletion and the other with a microduplication of the CNTN6 gene, both of paternal origin (Kashevarova et al., 2014; Tassano et al., 2018). Here, CNTN6 is linked to microcephaly.