found that overexpression of miR-190a-3p results in the inactivation of the PI3K/AKT signaling pathway in glioma (106), suggesting that the silencing of this miRNA observed in our breast cancer tissue samples compared to controls could contribute to increased expression of genes encoding proteins of the PI3K/AKT pathway, enhancing the metastatic potential of cancer cells. This evidence concerns the gene PIK3CA and central nervous system cancer.