Previous studies have reported that SEPTIN12 mutations, including c.266C > T/p; Thr89Met (Kuo et al., 2012), c.616del; p.A206Pfs*10 (Li et al., 2021), c.589G > A/p; D197N (Kuo et al., 2012), E282A (Quarantani et al., 2023), and c.474G > A (Rafaee et al., 2020) cause male infertility. This evidence concerns the gene SEPTIN12 and male infertility.