Hsf1 deletion also leads to reduced tumor burden in other mouse models, including chemical carcinogenesis-driven hepatocellular carcinoma, mammary tumorigenesis resulting from p53 and neurofibromatosis type 1 (Nf1) loss, and lymphomas caused by p53-deficiency (Min et al., 2007; Jin et al., 2011; Xi et al., 2012). This evidence concerns the gene TP53 and hepatocellular carcinoma.