HSF1 and T-cell leukemia: Besides, inhibiting HSF1 with KRIBB11 disrupts these pathways, reduces MDM2 and other survival proteins, induces apoptosis, and enhances sensitivity to HSP90 inhibitors, making HSF1 a promising target to overcome DNA damage repair-mediated chemoresistance in adult T-cell leukemia (Ishikawa and Mori, 2023).