The most well-studied interaction is exosomal EphA2 derived from tumor serum that contributes to vesicular pathfinding, angiogenesis, and cell migration via Eph-ephrin forward signaling and is a potential diagnostic biomarker for several cancers (Fan et al., 2018; Gao et al., 2021; Han et al., 2022; Wei et al., 2020). This evidence concerns the gene EPHA2 and cancer.