Consistent with previous studies (Zhao et al., 2024; Dhadhal and Nampoothiri, 2022; Javidan et al., 2022), our research shows a downregulation of LIFR in tissues from patients with polycystic ovary syndrome (PCOS), suggesting that LIFR may influence ovarian function and embryo development by modulating the ER stress response. Here, LIFR is linked to polycystic ovary syndrome.