NFKB1 and polycystic ovary syndrome: GSEA further identified several pathways enriched in PCOS, including IL3, PI3K-CI, NFKB, MAPK, TNFR2 non-canonical NFKB, and IL12 signaling and FcεRI-mediated MAPK activation (Figures 4A–H; Table 4), reflecting a strong association with immune response activation and inflammation-related pathways.