COQ8B and epilepsy: Several CoQ biosynthesis genes have been implicated in epilepsy including COQ1-PDSS2, COQ2, COQ4, COQ5, COQ6, COQ8-ADCK3, COQ8-ADCK4, and COQ9, with COQ2, COQ4, and COQ8-ADCK3 mutations being more frequently associated with seizures (124).