In this study, the Lp-PLA2 level in the VD group and the AD group was significantly higher than that in the control group, and the Lp-PLA2 level was negatively correlated with the MMSE score of dementia patients, indicating that the higher the Lp-PLA2 level, the more serious the cognitive impairment of patients, which is consistent with the viewpoint of Maher-Edwards et al. (20). The gene discussed is PLA2G7; the disease is Cognitive impairment.