Oxidative stress is an imbalance between free radicals-antioxidants in the body, resulting in damage and contributing to various diseases, such as cancer, diabetes, neurodegenerative diseases, and aging.17 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a protein that plays an important role in preventing oxidative stress. The gene discussed is NFE2L2; the disease is neurodegenerative disease.