Platelet-derived growth factor receptors alpha and beta (PDGFRA and PDGFRB) are membrane receptors that are involved in transduction of extra-cellular signals into cells, which is a critical process in a number of diseases, including many types of cancer, such as prostate cancer, ovarian, breast, pancreatic, and liver cancer, immune-mediated pathologies like systemic sclerosis (SSc), and viral infections (Mozzicafreddo et al., 2023). The gene discussed is PDGFRB; the disease is systemic sclerosis.